HEMATOPOIESIS AND STEM CELLS Significant mobilization of both conventional and regulatory T cells with AMD3100
نویسندگان
چکیده
1Department of Pediatrics, Children’s Healthcare of Atlanta and the Emory Transplant Center, Emory University School of Medicine, Atlanta, GA; 2Department of Microbiology and Immunology, Uniformed Services University of Health Sciences, Bethesda, MD; 3Emory Transplant Center, Department of Surgery, Emory University School of Medicine, Atlanta, GA; 4Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD; and 5Department of Genetics, University of Georgia, Athens, GA
منابع مشابه
Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells.
BACKGROUND Although mobilization of hematopoietic stem cells and hematopoietic progenitor cells can be achieved with a combination of granulocyte colony-stimulating factor and plerixafor (AMD3100), improving approaches for hematopoietic progenitor cell mobilization is clinically important. DESIGN AND METHODS Heparan sulfate proteoglycans are ubiquitous macromolecules associated with the extra...
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Background and Objective: Mobilization of Hematopoietic Stem Cells (HSCs) for transplantation and the importance of -adrenergic signals in induction of this process have been well investigated. However, little is known about the role of -adrenergic signals in mobilization of HSCs and factors influenced by these signals. The Chemokine Stromal Derived Factor -1 (SDF-1) which is expressed by hum...
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CXCL12 and VCAM1 retain hematopoietic stem cells (HSCs) in the BM, but the factors mediating HSC egress from the BM to the blood are not known. The sphingosine-1-phosphate receptor 1 (S1P1) is expressed on HSCs, and S1P facilitates the egress of committed hematopoietic progenitors from the BM into the blood. In the present study, we show that both the S1P gradient between the BM and the blood a...
متن کاملSphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice.
CXCL12 and VCAM1 retain hematopoietic stem cells (HSCs) in the BM, but the factors mediating HSC egress from the BM to the blood are not known. The sphingosine-1-phosphate receptor 1 (S1P(1)) is expressed on HSCs, and S1P facilitates the egress of committed hematopoietic progenitors from the BM into the blood. In the present study, we show that both the S1P gradient between the BM and the blood...
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Mobilization of hematopoietic stem and progenitor cells (HSPCs) from bone marrow into the blood circulation has been widely used for hematopoietic transplantation. However, the current methods of cytokine- or small-molecule-stimulated HSPC mobilization are far from satisfactory. New mobilizing agents are needed to increase the number of stem cells in peripheral blood for effective reconstitutio...
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